Bigger numbers needed!

Bigger numbers needed!

Numbers needed to treat to prevent tuberculosis.

A new action framework advocacy document for tuberculosis elimination in low-incidence countries has recently been published in this journal [1]. We completely agree with the importance of addressing the goal of elimination of tuberculosis, which may be achievable in regions such as Western Europe and North America, but we are concerned that this goal may be overly ambitious at this point in ti...

Measures of clinical effectiveness: the numbers needed to treat.

The bigger picture concepts

If a concept is not well defined, it can be abused. This is particularly true of complexity, an inherently interdisciplinary concept that has penetrated a range of intellectual fields from physics to linguistics, but with no underlying, unified theory. Complexity has become a popular buzzword that is used in the hope of gaining attention or funding — institutes and research networks associated ...

Is Bigger Really Badder?

Increasing attention is being focused on the role(s) that obesity may play in the development of cardiovascular disease, particularly congestive heart failure (CHF).1,2 Several indirect or associated effects are potential culprits. For example, obesity is strongly associated with many atherosclerotic risk factors, including arterial hypertension, insulin resistance, diabetes, and dyslipidemia.3...